Tangential Flow Filtration (TFF) Calculator

Calculate ultrafiltration/diafiltration membrane flux (LMH), transmembrane pressure (TMP), wall shear rate, and volumetric concentration factor (VCF).

Pressures & Membrane Area

Feed Pressure P_feed (psig):

Retentate Pressure P_ret (psig):

Permeate Pressure P_perm (psig):

Membrane Area A (m²):

Filtration Volume & Rate

Permeate Flow Rate (mL/min):

Initial Feed Volume V₀ (L):

Target Final Retentate Volume (L):

TFF Hydrodynamics & Flux

Transmembrane Pressure (TMP):

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Channel Pressure Drop (ΔP):

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Membrane Flux J (LMH):

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Concentration Factor (VCF):

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Estimated Concentration Time:

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Frequently Asked Questions

What is Transmembrane Pressure (TMP)?

TMP is the driving force for filtration across a tangential flow membrane, defined as average retentate-channel pressure minus permeate pressure: TMP = (Pfeed + Pret)/2 - Pperm.

What does LMH mean in membrane operations?

LMH stands for Liters per Square Meter per Hour (L/m²/h), the universally accepted metric for measuring membrane permeate volumetric flux.

How many diafiltration volumes (DV) are needed for 99% buffer exchange?

Buffer clearance follows first-order washout kinetics: Clearance = 1 - exp(-DV). 5 DV achieves 99.3% buffer exchange, and 7 DV achieves 99.9% exchange.