Drug Bioavailability & Trapezoidal AUC Calculator

Determine absolute systemic bioavailability ($F$), numerical Area Under the Curve ($AUC_{0-\infty}$), peak concentration ($C_{max}$), and clearance ratios.

Oral & Intravenous Clinical Doses

Oral Dose Administered (mg):

IV Reference Dose (mg):

Oral AUC_0-inf (mg·h/L):

IV Reference AUC_0-inf (mg·h/L):

Oral Peak C_max (mg/L):

Time to Peak T_max (hours):

Bioavailability & Exposure Analysis

Absolute Bioavailability (F)

Systemic Clearance (CL)

AUC Oral/IV Ratio

Dose-Norm Exposure

First-Pass Loss

Trapezoidal AUC Rule & Biopharmaceutics

Linear trapezoid AUC = ∑ 0.5 · (C_i + C_i+1) · Δt | Residual tail: C_last / k_e

Recommended Tools & Equipment

Tested hardware and components for high reliability

100% Free Tool Zero Sign-Up

Drug Bioavailability & Trapezoidal AUC Calculator

Oral & Intravenous Clinical Doses

Bioavailability & Exposure Analysis

Frequently Asked Questions