ECMO Membrane Oxygenator Gas Transfer Calculator
Extracorporeal life support & cardiopulmonary bypass: Determine oxygen uptake ($V_{O2}$), carbon dioxide elimination ($V_{CO2}$), and sweep gas flow requirements for polymethylpentene ($PMP$) hollow-fiber oxygenators.
Blood Circuit & Hematocrit
Extracorporeal pump flow (adult ~4–5 L/min)
Standard target on ECMO ~10–12 g/dL
Pre- and Post-Oxygenator Blood Gases
Venous drainage saturation
Oxygenated return saturation (~100%)
Inlet venous carbon dioxide tension
Fresh gas ventilating the hollow fibers
Hüfner's Hemoglobin Constant
Each gram of fully saturated hemoglobin binds $1.34\,\text{mL of } O_2$:
$$C_{O2} = 1.34 \cdot [\text{Hb}] \cdot \frac{\text{Sat}\%}{100} + 0.0031 \cdot P_{O2}$$
Oxygen transfer rate: $V_{O2} = Q_B \cdot (C_{aO2} - C_{vO2}) \cdot 10$.
Gas Exchange Rates
Oxygen Delivery Rate (V_O₂)
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CO₂ Elimination Rate (V_CO₂)
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Blood Oxygen Content (mL O₂ / dL)
Post-Oxygenator Content (C_aO₂)
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Pre-Oxygenator Content (C_vO₂)
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Sweep Gas & Ventilatory Mechanics
Sweep Gas-to-Blood Ratio:
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Estimated Post-Ox PaCO₂:
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Adult Metabolic Support Status:
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