Hepatic Clearance & Michaelis-Menten Metabolism Calculator
Determine hepatic intrinsic clearance ($CL_{int}$), well-stirred liver model clearance ($CL_H$), hepatic extraction ratio ($E_H$), and first-pass oral bioavailability ($F_H$).
Enzyme Kinetics & Liver Perfusion
Normal adult liver: ~90 L/h (1.5 L/min)
Free fraction (e.g. 0.10 = 90% protein bound)
When C_u << K_m, metabolism is linear
Hepatic Extraction & Clearance Output
Hepatic Clearance (CL_H)
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Hepatic Extraction Ratio (E_H)
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Intrinsic CL_int
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Metabolic Rate v
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Saturation Level
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Well-Stirred Venous Equilibrium Model
CL_H = Q_H · (f_u · CL_int) / (Q_H + f_u · CL_int)
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